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The hippocampus, a structure critical for memory formation and spatial learning, expresses GLP-1 receptor levels, and preclinical studies demonstrate that GLP-1 receptor activation enhances synaptic plasticity and neurogenesis in this region

It was meant to rule out deficiency, but the result points the other direction

Moreover, the benefits of melatonin are appreciable in mitochondria isolated from aged rodent brains where chronic treatment allows for antiapoptotic effects and increased cellular respiration as the young mitochondria counterparts