is tradjenta a glp-1 Should I discontinue Tradjenta (linagliptin)

Microdosing Semaglutide Split-dosing protocols for improved tolerability

This effect is blocked by GLP-1RA, which prevents optic nerve axonopathy

Additionally, semaglutide slows gastric emptying, prolonging the sensation of fullness and reducing the frequency of hunger signals

Administration of linagliptin (10 mg/kg/day), a DPP-4 inhibitor, to ApoE / mice, an animal model of atherosclerosis, decreased inflammatory molecule expression and macrophage infiltration in the atherosclerotic aorta [65]

But "improvement" in this context means TSH levels changed, and that can go in either direction depending on your current dose