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However, this association does not imply causationelevated B12 often serves as a biomarker for serious underlying disease rather than being directly harmful

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[11] Women from South Asian backgrounds show higher rates of B12 deficiency in UK populations and may benefit from assessment

After each increase, blood levels peak over 24 to 72 hours, when nausea and fullness are most likely to return. These effects usually ease during the four-week hold

However, as with any procedure, there may be certain risks and complications such as: Infection at the injection site Reaction at the injection site Pain or swelling at the injection site Septic arthritis Acute arthritis Inflammation of the joint lining Nerve Injury Summary Intra-articular knee injections are a safe and effective procedure to treat pain from conditions such as osteoarthritis and rheumatoid arthritis