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Contraindications must also be assessed carefully to ensure safety: Known allergies to ingredients (especially sulfa-containing methionine)

No special treatment was provided to the control group (CON)

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Combining insulin and semaglutide significantly increases hypoglycemia risk because both lower blood glucose

Research applications require consideration of the peptide's selectivity mechanisms and potential off-target effects, while the well-characterized mechanism provides foundation for power calculations and experimental planning in senescence research applications across diverse biological systems and disease models