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Both induced and genetically manipulated arthritis models have been extensively used to investigate bone resorption and formation in RA (Table 2 and Figure 2)

While rare, some individuals may experience mild gastrointestinal discomfort

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For example, it was recently found that that replacement of growth hormone could improve cerebral metabolism, knowledge, memory, and behavior in mild cognitive impairement (70), and that replacement of a natural signaling peptide called Gonadotropin-Releasing Hormone (GnRH) could significantly improve learning and cognition in Down's syndrome patients (71)

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