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Eli Lilly's retatrutide hits primary endpoint in Phase III TRIUMPH-4 obesity and knee osteoarthritis trial

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15 Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm G R

In addition to classic WM lesions, demyelination occurs in the cortices in MS and these demyelinated plaques are referred to as cortical lesions

In line with these data, the GLP-1R has been found to be co-expressed in ARC POMC neurons in both rats (Sandoval et al., 2008) and mice (Ronnekleiv et al., 2014) suggesting that GLP-1 can act directly on these neurons