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Nature Reviews Endocrinology , 12(12), 699712

The mechanisms driving central sensitization include elevated substance P, reduced descending pain inhibition, altered glutamate signaling, and microglial activation in the central nervous system

A deficiency in vitamin K can result in bruising or bleeding

Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo

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