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Results: Our observational cohort included 24,888 people (51.4% female, median age 58 years (IQR: 51-67))

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JMs background metformin was continued As stressed in the ADA Standards of Care, metformin remains the recommended first-line pharmacologic therapy in patients with T2D and should be continued with the addition of other glucose-lowering therapies in those who can tolerate and do not have a contraindication to metformin therapy

These additives can affect the pH and osmolality of the solution, which influences injection site comfort