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Secretion: ABCG2, OAT1/3 (basolateral), MRP4, and NPT1/4 (apical) ensure urate secretion from blood into the tubular lumen (Yu et al., 2023

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The relationship between aSYN pathology, cell death, and symptoms in PD remains uncertain, despite the clear evidence of widespread aSYN-laden LP in the disease and the ability of aSYN aggregates to spread in animal models