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The delicate peptide chains can break apart from mechanical stress

Immune checkpoint inhibitors have shown good therapeutic efficacy in most malignancies, but have limited efficacy in patients with ovarian cancer

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This is further supported by the finding that SOD activity is increased during active disease and returns to normal in remission (157).Additionally, the presence of oxidative damage and the inhibition of catalase, an antioxidant enzyme, in CD patients immune cells further underscores oxidative stresss role in the disease (158)

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