The GIP hormone plays a significant role in insulin secretion and fat metabolism
Researchers are investigating genetic variants in GLP-1 receptor pathways, gut microbiome profiles, and baseline hormone levels to determine who will respond best to GLP-1 therapy, who might benefit from dual agonists, and who is more prone to side effects
The TCGA database provide a unique opportunity to explore genes such as GLP-1R in a clinical context, enhancing our understanding of their contribution to cancer development and progression at the pan-cancer level [50,51,52]
Based on above results, we propose that hepatic TR could serve as an exploitable therapeutic target for treating diabetes
Tirzepatide is used for the treatment of obesity, and its side effects include hair loss, nausea and diarrhoea