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Unlike some other compounds in its class, ipamorelin avoids triggering cortisol and prolactin spikes, which enhances its overall tolerability

In fact, mice with hepatocyte-specific DPP-4 knockdown have a significant reduction in serum DPP-4 activity and reduced adipose tissue inflammation, insulin resistance, and glucose intolerance [20]

The two effects partially cancel out, and many patients report less prednisone-related weight gain when they're already on Zepbound

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Kageyama and Suda, 2009)