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Medical sources list mild GI reactions with collagen, especially when intake is high or increases suddenly

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doi:10.1016/j.freeradbiomed.2007.03.033 Schoeneberger H, Belz K, Schenk B, Fulda S (2015) Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death

While the precise pathophysiological mechanisms of ALD remain incompletely understood, strong evidence links inflammation to its progression