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Critical knowledge gaps persist in both unresolved basic enzymology and the comprehensive understanding of their multi-level regulation

This started with the launch of the long-acting/extended release exenatide microspheres, followed by dulaglutide and albiglutide in 2014.10 Interestingly, perhaps the most successful of this wave of once-weekly products, dulaglutide, was launched in a three-step autoinjector, which compared favourably with formulations that required more complicated preparation steps for the user

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