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Vitiligo genetics Vitiligo is a complex disease in which the risk attributed to the genetic component is estimated at 75% to 83%, whereas environmental factors would comprehend the remaining 20%

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miRNAs like miR-148a and miR-340 regulate pigmentation by modulating MITF and dendrite formation, while miR-21 enhances anti-apoptotic and proliferative pathways in melanocytes post-UVA exposure, indicating multifaceted roles in pigmentation and survival 104,105

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