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The largest retrospective analyses focus on patients with both diabetes and RA already on conventional DMARDs, making it difficult to isolate GLP-1 benefits

Ibuprofen had relatively little effect on B cell viability (Figure 8)

The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo