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Several therapeutic strategies are analyzed in preclinical studies to find an appropriate and effective drug resistance and tumor recurrence solution

Other genes, although with ARE motifs, present CpG islands in their proximal promoters such as GCLC and GCLM, which are characterized by significant association of active histone codes such as H3K4Me1-3, H3K9Ac, H3K27Ac, and H3K79Me2, suggesting a regulatory role of CpG islands in chromatin modifications

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Ogbonnaya ES, Clarke G, Shanahan F, Dinan TG, Cryan JF, OLeary OF

Oxidative stress can lead to damage to DNA, proteins, and cell membranes, negatively impacting cell health