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Traditional systemic therapy I: methotrexate and cyclosporine

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Inhibitors of GH Secretion Several factors can suppress GH release: Somatostatin (also from the hypothalamus) directly inhibits GH secretion Hyperglycemia (high blood sugar) Elevated IGF-1 levels (negative feedback) Chronic stress or high cortisol levels Poor sleep and circadian disruption GHRH Analogues: Peptides That Mimic Natural Signals Several peptides have been developed to mimic the action of GHRH, improving GH release in a physiologically balanced way

doi: 10.1016/0041-008x(83)90190-4

COVID-19: immunopathogenesis and Immunotherapeutics