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Jan-Apr 2020;28(2):2309499020905993
J Control Release 352:1524
References Agere S, Akhtar N, Riegsecker S, Ahmed S (2015) Epigallocatechin-3-gallate (egcg) inhibits rantes/ccl5 induced mmp-1 and mmp-13 expression in human rheumatoid arthritis synovial fibroblasts
Increasing evidence indicates that CHE, as a benzophenanthridine alkaloid, exhibits its excellent anticancer activity as CHE can intervene in tumor progression and inhibit tumor growth in multiple ways, such as induction of cancer cell apoptosis, cell cycle arrest, prevention of tumor invasion and metastasis, autophagy-mediated cell death, bind selectively to telomeric G-quadruplex and strongly inhibit the telomerase activity through G-quadruplex stabilization, reactive oxygen species (ROS), mitogen-activated protein kinase (MAPK), and PKC