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Our results not only show that the yeast-produced PV1-SC7 sVLP is a promising vaccine candidate with high-yield production capacity and desirable immunogenicity demonstrated in a mouse model, but also reveal structural mechanisms governing PV1-SC7 sVLP assembly and D-antigenicity

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Further study is needed to understand the consequences of the greater diversity of LN metastases, as well as the selective pressures in different organs