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The efficacy of receptor agonists is also different in animals with and without diabetes as levels of insulin and blood glucose can affect the pathophysiology and outcomes of stroke (185, 186)

Combining EXE with PIO also suppressed the significant change in body weight induced by PIO compared to weight gain found after its administration

For example, the next generation of probiotics (NGP) has shown potential as disease-specific therapeutics and will help us understand the effectiveness and safety of probiotic microorganisms (127, 128)

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While these events are generally manageable, they can notably impact treatment adherence and quality of life