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Prescription rate of GLP-1s based on diagnosis Source: Piaopiao, L et al JAMA Network Open October 31, 2025 Research published in JAMA Network Open evaluated trends in prescribing of GLP-1 agents from 2010 through the end of 2024 using the Cosmos data warehouse, which has at least some medical records for 300 million Americans

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Tirzepatide is administered as a once-weekly subcutaneous injection, starting at 2.5 mg for 4 weeks (an initiation dose), then typically increasing to 5 mg, with possible further increases to 7.5, 10, 12.5, or 15 mg based on clinical response and tolerability