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One of the earliest symptoms of vitamin C deficiency is fatigue, thought to be related to decreased synthesis of L-carnitine (41)

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Older melanoma patients aged 75 and above retain responsiveness to anti-PD1 therapy: results of a retrospective single-institution cohort study

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Animal experiments The Animal Care and Use Committee of Renmin Hospital of Wuhan University approved all animal experiments (WDRM 20200604), which complied with the Guide for the Care and Use of Laboratory Animals (NIH Publication No