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In addition, melatonin inhibits the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) 75 and limits the production of excessive amounts of prostanoids and leukotrienes and nitric oxide (NO), as well as other mediators of the inflammatory process, such as chemokines and adhesion molecules 73,76 (Fig

Previously, these treatments required patients to self-administer injections on a regular basis, which could be a barrier to adherence for many individuals

The standard forms of Zepbound, which come in an auto-injector pen, can cost more than $1,000 per month without insurance

While generally well-tolerated, research has also addressed safety concerns, focusing on appropriate dosing to mitigate risks and ensure effective outcomes (5)

Up to 37% of the population experience nocturnal leg cramps(1)