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T-cells were spun down on the antibodies and incubated at 37C for the indicated time points

We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors

Lower-dose maintenance and full discontinuation produce different outcomes

Redox signaling: nitrosylation and related target interactions of nitric oxide

They are vitamin B12, choline, methione, and inositol