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The transmural nature of the inflammation gives rise to characteristic complications including fistulae , abscesses , strictures , and bowel obstruction , all of which have distinct ICD-10-CM coding implications

Mar 2019;110:31-37

It has been used in trials for ulcerative colitis and multiple sclerosis, with a very safe profile (LD1 not achieved), as previously reviewed[8-20]

At this stage, the most defensible position is that timing likely plays a minor role compared to overall exposure and consistency