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L-Carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitisa randomized and controlled clinical trial

Heart Fail 24 , 4131 (2022)

Thus, a number of studies have shown a positive association between plasma DPP-4 activity and BMI in non-diabetic individuals ( in vitro were found to be positively correlated with adipocyte size as well as with anthropometric parameters such as BMI, waist circumference and percent body fat ( Dpp4 expression is reported to be relatively low in mouse adipocytes and not to be markedly increased after high fat feeding ( However, there is also evidence pointing toward a hepatic origin of circulating DPP-4, and it has been suggested that the inclusion of some patients with unidentified liver disease may have contributed to the conflicting data regarding the association of plasma DPP-4 activity and T2DM

All of this can lead to body weight reduction and weight control

Disrupted iron metabolism, particularly iron accumulation in joint tissues, contributes to oxidative damage and inflammation, suggesting a potential link to disease progression