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After 26 weeks, the levels of hs-CRP and endothelin-1 decreased (27.5% and 18.75%, respectively) in the exenatide arm whereas the levels of fibrinogen, monocyte chemoattractant protein-1, leptin and endothelin-1 increased in the insulin glargine arm (13.4%, 30.2%, 47.5%, and 80%, respectively) [45]

In one trial, about 66 per cent of people on trizepatide lost more than 10 per cent of their body weight in one year, compared to 41 per cent on semaglutide

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