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Acknowledgements The authors are thankful to Integral University, Lucknow, and Eras Lucknow Medical College and Hospital, Era University, Lucknow for providing their assistance during this work

When IGF-1 LR3 is mobile in the body, it functions differently in individual types of tissues

Hydration is important for the enzymes responsible for desquamation, which helps dead cells shed properly

In vitro models of ECD allow the study of cellular and molecular mechanisms of disease and provide a research platform for screening potential therapeutic agents

Mitigation strategies include strict sun protection during treatment, using moderate rather than aggressive microneedling depths, incorporating niacinamide which helps prevent PIH, considering patch testing before full-face treatment, and being prepared to pause treatment if significant PIH develops