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6.3 Clinical applications in cardiovascular disease prevention Recent American College of Cardiology/American Heart Association guidelines advocate for the use of GLP-1RAs in patients with T2DM at high risk of atherosclerotic cardiovascular disease (ASCVD), irrespective of well-controlled glucose levels, based on the clinical trials mandated by FDA-issued industry guidelines in December 2008 to assess the cardiovascular effects of new diabetic therapies (247)

Nitric oxide is another component that may play a role in central nervous system pathology, as it can present as both a reactive oxygen species and a neurotransmitter in the central nervous system, (4)

For all forms of symptomatic gallstone disease, surgery is the mainstay of conventional treatment