As the FOXO proteins are regulated by SGK1 and Akt, SGK can be the mTORC2 effector, whereas Akt appears to be a more subtle modulator (Liu and Sabatini, 2020a
Maintaining an optimal level of glutathione appears to be important for supporting cognitive function, especially during aging.* The normal process of aging is associated with a decrease in glutathione activity, which can result in increased oxidative activity.* Less than an optimum level of glutathione is observed in individuals experiencing a decline in cognitive function.* Conversely, individuals who live to 100 tend to have higher glutathione activity.*
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NADPH helps regenerate glutathione, which creates an important link between these systems
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