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The following are common causes: Overuse: Repetitive overhead motion in sports (e.g., tennis, swimming) or occupations (e.g., painters, mechanics) Impingement syndrome: Compression of rotator cuff tendons under the acromion during arm elevation Age-related degeneration: Reduced blood flow and tendon elasticity in individuals over 40 Poor posture: Forward head and shoulder positioning increases stress on shoulder stabilizers Previous shoulder injuries: Dislocations or fractures can alter shoulder mechanics and increase risk How Is Rotator Cuff Tendinopathy Diagnosed

In clinical practice, while physical therapy, analgesic medications, and even joint replacement surgery can alleviate symptoms, no currently available drug therapies can effectively halt or reverse cartilage degeneration (Cho et al., 2021

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Nanomaterials 7 , 225 (2017)