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This helps transition the injury from the inflammatory phase to the proliferative and remodeling phases more efficiently, without the need for NSAIDs that may impair certain aspects of tissue healing

As food and waste material move more slowly through the intestines, water absorption likely increases, which can lead to harder, drier stools and subsequent constipation

Already in the 1940s, Charles Huggins and his colleagues demonstrated the effectiveness of ADT through surgical castration, which removes the major source of systemic androgen synthesis, as a treatment for advanced metastatic CaP [5, 6]

The alendronate group demonstrated significant improvement in morphological features of bony samples with obvious records of apparent intact trabecular bone with up to a 2.4-fold increase of relative trabecular bony area