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The ISAP trial (ISRCTN71283871) is assessing whether oral semaglutide (up to 14 mg qd) over a 52-week treatment period can mitigate tau deposition and neuroinflammatory responses in individuals at risk for preclinical AD

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from weeks 2 to 4, rats in all the T2DM groups had lower body weight than those in the normal group, among which the body weight of rats in the T2DM + RYGB group increased slowly post-operation, slightly higher than that in T2DM and T2DM + sham