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Importantly, diselenide linkages are dual-responsive, as they are susceptible not only to GSH reduction but also to oxidation by reactive oxygen species (ROS), such as hydrogen peroxide [59]

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Case reports and expert consensus instead highlight that tirzepatide alone achieves superior long-term weight loss (average 22 pounds at 21 weeks in STEP trials) without the tolerance decay that limits phentermine to 12 weeks of use