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The newly approved oral GLP-1 orforglipron (Foundayo) is a distinct non-peptide small molecule with its own independent patent timeline.

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It has been shown that roGFP2 is almost fully reduced in intact tissues and that a treatment with the GSH1 inhibitor BSO or the electrophilic xenobiotic 1-chloro-2,4-dinitrobenzene led to fully oxidized state of the biosensor accompanied by decreased fluorescence intensity 52

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Yousuf et al

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