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Individuals with diabetes have an increased risk of developing neurodegenerative diseases, and the combination of cerebral and peripheral insulin resistance constitutes one of the main mechanisms underlying the initiation and progression of neurodegenerative diseases [23]

In the overweight/obese group, the sample size was 979 patients

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Diabetologia 56:25822592 Bailey CJ, Gross JL, Pieters A, Bastien A, List JF (2010) Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial