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While -blockers are effective antihypertensive agents, concerns have been raised regarding their potential adverse effects on metabolic parameters such as lipid profiles and insulin sensitivity, as well as their propensity to induce weight gain in some individuals (Pischon and Sharma, 2001)

Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or Gastrointestinal adverse events in the SUSTAIN 1 to 5 trials

But there are nuances

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In a case-control study, which included 184 participants with CAD and 516 healthy controls, low plasma PLP levels ( 30 nmol/L) at baseline to be associated with an increased risk of cardiovascular events, but this overall association was not significant when accounting for inflammation (32)