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For patients with type 2 diabetes or established cardiovascular disease, trials including SUSTAIN 6 and later outcome studies have demonstrated reduced rates of stroke, heart attack, and major adverse cardiac events with semaglutide and related drugs

2002 Apr;318(1-2):51-61

By improving glycaemic control and promoting weight losstwo established benefits of GLP-1 receptor agonistsRybelsus may help reduce hepatic fat accumulation in some individuals, although it is not licensed for the treatment of NAFLD

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Individuals with a history of medullary thyroid cancer, gallbladder disease, pancreatitis, or multiple endocrine neoplasia syndrome type 2 (MEN2) should avoid taking it