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Sensitivity analysis to mitigate bias concerning ethnic and geographical origin To assess whether cross-study population background would influence our external-control comparisons, we performed a sensitivity analysis using three independent PBMC single-cell RNA sequencing datasets generated from China/Asia-based cohorts (GSE279452 60 , GSE206295 61 , and GSE168732 62 )

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For example, phosphorylation usually occurs extensively in the metabolic process of cellular metabolism, whereas metabolic reprogramming is a critical characteristic of tumor adaptation

Response: We acknowledge commenters' concerns and encourage hospitals, REHs, and ASCs to continue to close identified gaps in patient care