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[5] Wee, L.E

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A major breakthrough in 2023 was the introduction of glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist tirzepatide, which activates both receptors and has shown superior glucose-lowering and weight-reducing effects in both clinical trials and real-world Japanese settings

Compared to the docking pose in hTYR, CME_c loses the hydrogen bond with H348 and shifts closer to the CuA site during the simulation, whereas CME_d exhibits only minor conformational changes (Fig