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Side Effects All three medications share similar side effects due to their common active ingredient: Most Common Side Effects: Nausea (most common when starting or increasing dose) Vomiting Diarrhea Constipation Abdominal pain Headache Fatigue Serious Side Effects (Rare): Thyroid tumors (including medullary thyroid carcinoma) Pancreatitis Gallbladder problems Kidney problems Diabetic retinopathy complications Severe allergic reactions Important : These medications carry a boxed warning about thyroid C-cell tumors and should not be used by people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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They also may contain unlisted or dangerous ingredients, such as solvents, heavy metals, glass, plastic, fibers, bacteria, fungi or endotoxins

TNF- was measured in the DRG and SC tissues during phases 1 and 2