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Arzneimittelforschung 1982;32(3):293-297

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Semaglutide works extensively through this bidirectional communication system, influencing neural circuits in the hypothalamus and other brain regions involved in appetite regulation

Heartburn is also more likely Heartburn is already more common on oral semaglutide than on the injectable form, for reasons related to the SNAC absorption mechanism and slowed gastric emptying. Alcohol relaxes the lower oesophageal sphincter - the valve between the stomach and oesophagus - which makes reflux more likely

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