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The pathogenic processes of ferroptosis involve an excessive iron metabolism that produces iron-dependent oxidative stress and causes damage to nucleic acids, proteins, and lipids that eventually induce cell death
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Nature 611 , 578584 (2022)
Tau has been shown to reduce secondary brain injury after CI by down-regulating the expression of matrix metalloproteinases-3 (MMP-3) in brain-injured rats, thereby protecting the BBB ( Furthermore, investigation revealed that BC and its active constituents, including Tau, TUDCA, and UDCA, can decrease lactate dehydrogenase levels, increase -GT content, raise TEER values, and decrease fluorescein sodium permeability coefficient
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