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An abnormal acylcarnitine profile and a high acylcarnitine to free carnitine ratio in the blood of patients with heart failure have been linked to disease severity and poor prognosis (53-55)
End-stage renal disease L-Carnitine and short/medium-chain acylcarnitine molecules are removed from the circulation during hemodialysis
Age-dependent decrease of carnitine content in muscle of mice and humans
Another randomized placebo-controlled trial in 2,330 patients with acute MI, L-carnitine therapy (9 g/day intravenously for five days, then 4 g/day orally for six months) did not affect the risk of heart failure and death six months after MI (50)
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