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14 However, interpretation of weight trajectory in STEP 4 is limited by the comparatively small magnitude of weight regain (owing to the shorter treatment duration and smaller initial weight loss in STEP 4 relative to STEP 1, and the continuation of lifestyle intervention)

43 In a prospective study, 12 months of once-weekly dulaglutide treatment preserved endothelial function in 13 MS patients, whereas parameters of endothelial function worsened in control subjects with MS, findings independent of changes in body weight

Both these genomic and additional non-genomic effects have actually been demonstrated with estradiol administration

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