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Main mechanisms involved are listed below: Direct effect of toxicant upon critical cellular systems: Hepatotoxicants can attack directly certain critical cellular targets like plasma membrane, mitochondria, endoplasmic reticulum, nucleus and lysosomes thus disrupting their activity

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Treg cells could not only interact with microglia (75), but also regulate their polarization from M1 to M2 via IL-10 pathway (80, 81)

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