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Supplementary Information Acknowledgements We acknowledge all patients participated and staff involved in the studies

Use only under medical supervision, especially if you have any existing medical condition, are taking other medicines, or are undergoing fertility treatment

Some patients benefit from remaining at a lower dose for a longer period before advancing

A 30-day supply of oral metformin tablets typically costs around $11, though exact prices will vary based on your pharmacy and dosage

9 ) shows that the presence of bafilomycin A1 (0.25 nM or 1 nM) did not have a significant effect on tamoxifen induced collateral sensitivity in CHO R C5 cells