This section reviews the roles of mtDNA-driven neuroinflammation in major NDDs and acute CNS injuries, detailing underlying molecular mechanisms, pathological consequences, and therapeutic prospects
doi: 10.1016/j.scib.2024.03.055 145 AlbertiniGDeneyerLOttestad-HansenSZhouYAtesGWalraveLet al
HO-1 has antioxidant properties in addition to the anti-inflammatory actions in different tissues [3335], derivatives of the reduced metabolites of the free heme groups, mainly by pattern recognition receptors (PRR) such as TLR-4 [36]
Alternative splicing at the C terminus further produces different isoforms (, , , , ) [56]
In proteinogenic amino acids, it bears the amine and the R group or side chain specific to each amino acid, as well as a hydrogen atom