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Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate

Bioequivalence and Biosimilar Considerations As patents begin to expire, demonstrating bioequivalence or biosimilarity for GLP-1 therapies is a key focus

10.1067/mai.2001.115569 134 SmallP.FrenkielS.BeckerA.BoisvertP.BouchardJ.CarrS.et al (2007)

The Deciding Factor If you take away one sentence from this article, take this one